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Most eukaryotic chromosomes bend back on them selves to sort a Bodily loop on the telomere. The existence of these loops, aptly named t-loops, was very first set up by electron microscopy of purified human telomeres that had been stripped in their proteins and stabilized by crosslinking (Griffith et

eTable 15. Time to event Assessment with the Top10 PheCodes positively linked to shorter telomere length, corrected for age, sexual intercourse, BMI and ethnicity This is the essence with the telomerase recruitment problem, which can be primarily solved because of the telomere protein TPP1 [30].